Neuroscientist Christos Constantinidis and Xiao - Jing Wang A Neural Circuit Basis for Spatial Working Memory
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چکیده
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منابع مشابه
A neural circuit basis for spatial working memory.
The maintenance of a mental image in memory over a time scale of seconds is mediated by the persistent discharges of neurons in a distributed brain network. The representation of the spatial location of a remembered visual stimulus has been studied most extensively and provides the best-understood model of how mnemonic information is encoded in the brain. Neural correlates of spatial working me...
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Working memory (WM) is a cognitive function for temporary maintenance and manipulation of information, which requires conversion of stimulus-driven signals into internal representations that are maintained across seconds-long mnemonic delays. Within primate prefrontal cortex (PFC), a critical node of the brain's WM network, neurons show stimulus-selective persistent activity during WM, but many...
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The concept of bell-shaped persistent neural activity represents a cornerstone of the theory for the internal representation of analog quantities, such as spatial location or head direction. Previous models, however, relied on the unrealistic assumption of network homogeneity. We investigate this issue in a network model where fine tuning of parameters is destroyed by heterogeneities in cellula...
متن کاملTemporally irregular mnemonic persistent activity in prefrontal neurons of monkeys during a delayed response task.
An important question in neuroscience is whether and how temporal patterns and fluctuations in neuronal spike trains contribute to information processing in the cortex. We have addressed this issue in the memory-related circuits of the prefrontal cortex by analyzing spike trains from a database of 229 neurons recorded in the dorsolateral prefrontal cortex of 4 macaque monkeys during the perform...
متن کاملSpeaker 1: Xiao-Jing Wang, China
I will first introduce the concept of “cognitive-type” cortical microcircuit exemplified by the prefrontal cortex. Since mental disorders primarily implicate cognitive-type brain systems such as the prefrontal cortex, rather than early sensory systems, progress in this area holds the promise for a new approach to psychiatric diagnosis and treatment. I will review experimental and computational ...
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